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Magnesium

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Magnesium in treatment-resistant depression (TRD)

 

There has been some speculation that magnesium deficiency can lead to depression. Cerebral spinal fluid (CSF) magnesium has been found low in treatment-resistant suicidal depression and in patients that have attempted suicide. Brain magnesium has been found low in TRD using phosphorus nuclear magnetic resonance spectroscopy, an accurate means for measuring brain magnesium. Blood and CSF magnesium do not appear well-correlated with major depression.[33] Magnesium chloride in relatively small doses was found to be as effective in the treatment of depressed elderly type 2 diabetics with hypomagnesemia as imipramine 50 mg daily.[34]

 

More info:

http://en.wikipedia.org/wiki/Magnesium#Magnesium_in_treatment-resistant_depression_.28TRD.29

http://www.ncbi.nlm.nih.gov/pubmed/16542786

http://www.ncbi.nlm.nih.gov/pubmed/19944540

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