Total Eclipse 91 Posted September 10 Quote Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS. This paper evaluates memantine as an augmentation therapy for treatment of anxiety. https://www.hindawi.com/journals/crips/2012/749796/ Quote Share this post Link to post Share on other sites